Related Experiment Video
Updated: May 29, 2025
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
Contamination effects in cluster randomised trials of TB interventions
K E LeGrand1, K Allel2, P Khan3
1Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine (LSHTM), London, UK.
Cluster randomised trials (CRTs) for tuberculosis (TB) interventions show mixed results, potentially due to contamination. Improved reporting and design are needed to accurately assess intervention impact.
Area of Science:
- Epidemiology
- Public Health
- Clinical Trials
Background:
- Cluster randomised trials (CRTs) for tuberculosis (TB) interventions yield inconsistent results.
- Contamination, due to population mobility, may dilute intervention effects in CRTs.
- Assessing population-level impact of TB interventions requires careful trial design.
Purpose of the Study:
- To systematically review literature on CRTs for TB interventions.
- To identify factors influencing the effectiveness and reporting of CRTs.
- To provide recommendations for improving CRT design and reporting.
Main Methods:
- Systematic literature review of CRTs for TB interventions.
- Extraction of trial design, intervention, outcome, population, and geographic data.
- Descriptive statistics and spatial analyses of included trials.
Main Results:
- 20 reports from seven CRTs were included after screening 1,039 abstracts.
- Median cluster number was 32; population per cluster ranged from 400-50,000.
- Potential for contamination was inconsistently reported; design limitations were acknowledged.
Conclusions:
- Gaps exist in the reporting of methods and results for CRTs.
- Standardised reporting tools are needed for CRTs.
- Improved CRT design and reporting practices are recommended to accurately measure TB intervention impact.
More Related Videos
09:02An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
Published on: February 17, 2014
09:33Visualizing Field Data Collection Procedures of Exposure and Biomarker Assessments for the Household Air Pollution Intervention Network Trial in India
Published on: December 23, 2022
Related Concept Videos
01:28Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
01:29Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
01:26Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
01:31Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
01:28Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...