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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
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Urgent Alert: Potential Risk of Dengue Infection Transmission Through Blood Transfusion in Iran
Zahra Taghinejad1, Mohammad Asgharzadeh2, Ali Akbar Pourfathollah3
1Department of Hematology and Blood Banking, Faculty of Basic Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Archives of Iranian Medicine
|February 1, 2025
Summary
Dengue infection poses a growing threat in Iran, transmissible via mosquitoes and healthcare settings. Implementing robust blood safety measures is crucial to prevent transfusion-transmitted dengue virus (TT-DENV).
Area of Science:
- Infectious Diseases
- Public Health
- Transfusion Medicine
Background:
- Dengue infection is an emerging public health concern in Iran, with documented cases.
- Transmission occurs through Aedes mosquito bites and potentially via nosocomial routes.
- The geographical spread and replication rate of mosquitoes increase the risk of dengue transmission.
Purpose of the Study:
- To highlight the risk of transfusion-transmitted dengue virus (TT-DENV).
- To emphasize the importance of enhancing blood safety policies in Iran.
- To propose strategies for mitigating TT-DENV risk.
Main Methods:
- Review of dengue transmission routes and public health implications.
- Analysis of potential blood safety vulnerabilities.
- Discussion of preventative strategies for TT-DENV.
Main Results:
- Dengue virus can be transmitted through blood transfusion.
- Effective donor screening, diagnostic testing, and pathogen reduction are key.
- Lookback programs are essential for managing transfusion-transmitted infections.
Conclusions:
- Strengthening blood safety protocols is vital to control TT-DENV in Iran.
- A multi-faceted approach including donor selection, testing, and pathogen reduction is recommended.
- Proactive measures are necessary to safeguard the blood supply against dengue.
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