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Dynamic roles of tumor-infiltrating B lymphocytes in cancer immunotherapy

Shishengnan Song1, Chong Wang2, Yangchao Chen3

  • 1Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.

Cancer Immunology, Immunotherapy : CII
|February 1, 2025
PubMed

The amazing diversity of B cells within the tumor microenvironment is the basis for the diverse development of B cell-based immunotherapies. Here, we focus on elucidating the mechanisms of tumor intervention mediated by four tumor-infiltrating B lymphocytes. Naive B cells present the initial antigen, germinal center B cell subsets enhance antibody affinity, and immunoglobulin subtypes exert multiple immune effects, while regulatory B cells establish immune tolerance. Together they reflect the complexity of the changing dynamics of cancer immunity. Additionally, we have investigated the dynamic effects of tumor-infiltrating B lymphocytes in immunotherapy and their relationship to prognosis, providing new insights into potential treatment strategies for patients.

Keywords:
Germinal centerTertiary lymphoid structuresTumor prognosisTumor-infiltrating B cellsTumor-infiltrating lymphocyte

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