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Utility Values of Health Status in Gastric Cancer: A Systematic Review.
Cristian Gonzalez1, Manuel Espinoza2, Matías Libuy1
1Escuela de Salud Pública, Universidad de Chile, Santiago de Chile, RM, Chile.
Value in Health Regional Issues
|February 1, 2025
Summary
This review synthesizes utility values for gastric cancer (GC) stages. Utility values decrease with advanced GC stages, highlighting the importance of patient preferences in healthcare decisions.
Area of Science:
- Health Economics
- Oncology
- Quality of Life Research
Background:
- Gastric cancer (GC) presents a significant global health burden, with available treatments often incurring high costs and impacting patient quality of life.
- Utility values, reflecting patient preferences for health states, are crucial for health and economic decision-making.
- Systematized information on utility values across different GC stages is currently limited.
Purpose of the Study:
- To systematically review and meta-analyze existing literature on utility values associated with various stages of gastric cancer.
- To provide an updated overview of GC utility values and analyze the relevance of disease stage.
- To inform healthcare policy and clinical decision-making by incorporating patient preferences.
Main Methods:
- A comprehensive literature search was conducted across PubMed, Embase, MEDLINE, and Cochrane Library.
- Studies reporting utility values derived from direct and indirect methods were selected for analysis.
- Extracted data underwent appraisal, followed by random-effects meta-analyses stratified by GC health states.
Main Results:
- Twelve studies encompassing 4585 patients were included in the meta-analysis.
- Mean utility values decreased progressively with GC stage: Stage I (0.77), Stage II (0.75), Stage III (0.70), and Stage IV (0.64).
- Significant heterogeneity was observed across all utility value estimates.
Conclusions:
- This systematic review offers a consolidated understanding of utility values in gastric cancer, emphasizing stage-specific differences.
- Patient preferences, as indicated by utility values, are vital considerations for policy development and clinical practice in GC management.
- The findings underscore the need to integrate patient-reported outcomes into healthcare economic evaluations.
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