Gentamicin-impregnated PMMA beads: an introduction and review

The local implantation of gentamicin-impregnated polymethylmethacrylate beads, in conjunction with the application of consistent surgical principles, has been used in Europe for the past decade. The system has proved successful in the treatment of osteomyelitis and soft tissue infections. It combines the benefits of high local antibiotic tissue levels with the achievement of primary wound closure. In this presentation, the advantages, disadvantages, and technical application of this new drug delivery system is introduced to the profession for consideration and future use.