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Updated: May 29, 2025

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
Published on: September 13, 2024
Potential benefits of ketone therapy as a novel immunometabolic treatment for schizophrenia
Karin Huizer1, Shubham Soni2, Mya A Schmidt2
1Parnassia Academy, Parnassia Psychiatric Institute, The Hague, the Netherlands; Department of Psychiatry and Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Department of Pathology, Erasmus Medical Center, Rotterdam, the Netherlands.
Abstract:
Therapeutic ketosis could target the potential bio-energetic pathophysiology of schizophrenia. Ideally, novel treatments also target the possible inflammatory aspects of schizophrenia. Adult mice (n = 30) were treated with ketone ester (KE) or vehicle for 3 days, next LPS- or PBS-injected. Brains were collected the next day. KE significantly attenuated the increased transcription of the pro-inflammatory cytokines Tnf-a, Il-6 and Il-1b, without affecting anti-inflammatory/immunomodulatory cytokines (Il-4, Il-10, Il-11) in whole brain. KE potently dampened neuro-inflammation in this acute inflammation mouse model. Ketone therapy could simultaneously target two possible pathophysiological pathways in schizophrenia. We encourage more research into the immunometabolic potential of therapeutic ketosis in schizophrenia.
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