Nanomaterial sensors for enhanced detection of serotonin

The detection of serotonin (5-HT), a critical neurotransmitter, has garnered significant attention in biosensor research because of its pivotal role in neurological and physiological processes. This narrative review highlights advancements in nanomaterial-based sensors designed to increase the sensitivity, specificity, and functionality of serotonin detection. Carbon-based nanomaterials, including carbon nanotubes (CNTs), graphene derivatives, and carbon nanofibers (CNFs), have demonstrated remarkable potential owing to their large surface area, superior electrical conductivity, and biocompatibility. These materials enable rapid electron transfer and selective serotonin adsorption, making them integral to electrochemical and wearable sensor technologies. Emerging technologies, including field-effect transistors (FETs), magnetoelastic biosensors, and molecularly imprinted polymers (MIPs), have demonstrated ultralow detection limits and real-time monitoring capabilities, suggesting promising applications for clinical diagnostics and personalized healthcare. Metal-based sensors, which utilize nanoparticles of gold, silver, and other metals, have also shown exceptional performance in serotonin detection through enhanced electrocatalysis and optical properties. This review underscores the transformative potential of nanomaterial-based sensors in serotonin detection, emphasizing their role in advancing neuroscience research, disease diagnostics, and therapeutic monitoring.