Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Hemostasis01:05

Introduction to Hemostasis

5.2K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
5.2K
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

5.0K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementing a Doctor-to-Doctor Telemedicine Network to Strengthen Rural Obstetric Care in Japan: Feasibility, Clinical Utility, and Educational Impact.

Cureus·2026
Same author

Increased placental villous macrophages in patients with antiphospholipid syndrome exacerbated during preterm pregnancy.

Placenta·2026
Same author

Blood Pressure, Urinalysis, and Edema Assessment in Perinatal Care: From Historical Foundations to Evidence-Based Practice.

JMA journal·2026
Same author

Therapeutic role of nifedipine in threatened preterm labor: Current evidence and future perspectives.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026
Same author

Recurrent Bleeding From Cervical Varices in Pregnancy: A Case Report and Literature Review.

Cureus·2025
Same author

Energy intake to meet total energy expenditure improves iron deficiency and metabolic suppression in female long-distance runners: A case series study with dietary intervention.

Women's health (London, England)·2025

Related Experiment Video

Updated: May 29, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

3.7K

Potential mechanisms for chorioamniotic membrane rupture after subchorionic hematoma.

Eriko Yasuda1, Yosuke Kawamura1, Yusuke Ueda1

  • 1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan.

American Journal of Obstetrics and Gynecology
|February 1, 2025
PubMed
Summary

Subchorionic hematoma triggers macrophages to transform amnion cells into myofibroblasts, potentially causing fibrosis and damage to chorioamniotic membranes, increasing risks for preterm birth.

Keywords:
Smad3TGF-βamnionepithelial-mesenchymal transitionintrauterine bleedingmacrophagesmouse modelmyofibroblastspregnancypreterm birthpreterm prelabor rupture of membranessubchorionic hematoma

More Related Videos

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

2.2K
Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
10:34

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

10.3K

Related Experiment Videos

Last Updated: May 29, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

3.7K
Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

2.2K
Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
10:34

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

10.3K

Area of Science:

  • Reproductive biology
  • Maternal-fetal medicine
  • Cellular and molecular pathology

Background:

  • Subchorionic hematoma is a known risk factor for preterm birth and prelabor rupture of membranes.
  • Persistent hematomas can lead to chronic abruption-oligohydramnios sequence.

Purpose of the Study:

  • To elucidate the mechanism by which subchorionic hematomas damage chorioamniotic membranes.
  • Investigate the role of macrophages and cellular changes in the amnion.

Main Methods:

  • Immunohistochemistry analyzed macrophages and myofibroblasts in human amnion from preterm deliveries with and without subchorionic hematoma.
  • An intrauterine hematoma mouse model and in vitro co-culture systems were used to study cellular responses.

Main Results:

  • Subchorionic hematoma increased iron-laden macrophages and myofibroblasts in the human amnion, indicating epithelial-mesenchymal transition.
  • Findings were corroborated in a mouse model.
  • In vitro studies showed M2 macrophages induce amnion mesenchymal cell transformation into myofibroblasts via the TGF-β‒Smad3 pathway.

Conclusions:

  • Subchorionic hematoma promotes macrophage migration to chorioamniotic membranes.
  • This activates amnion mesenchymal cells to become myofibroblasts, contributing to fibrosis and membrane damage.
  • These changes may underlie the increased risk of preterm birth associated with subchorionic hematoma.