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Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...

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The Everyday Function Intervention Trial (EFIT) protocol: A randomized clinical trial.

Lesley A Ross1, Courtney Fine1, Abigail T Stephan1

  • 1Clemson University, Department of Psychology and Institute for Engaged Aging, 418 Brackett Hall, Clemson, SC 29631, United States.

Contemporary Clinical Trials
|February 1, 2025
PubMed
Summary
This summary is machine-generated.

The Everyday Function Intervention Trial (EFIT) investigates how cognitive training preserves daily function in older adults. This study uses novel methods to understand the mechanisms behind cognitive training for Alzheimer's disease and related dementias prevention.

Keywords:
Brain trainingCognitive functionCognitive trainingEveryday functioning

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Area of Science:

  • Gerontology
  • Cognitive Neuroscience
  • Clinical Trials

Background:

  • Maintaining cognitive function and independence is crucial for older adults, particularly in preventing Alzheimer's disease and related dementias (ADRD).
  • Useful Field of View training (UFOVt) is a computerized program shown to preserve cognition and function, but its underlying mechanisms remain unclear.
  • The Everyday Function Intervention Trial (EFIT) was designed to explore these mechanisms.

Purpose of the Study:

  • To outline the protocol of the Everyday Function Intervention Trial (EFIT).
  • To assess potential cognitive, psychosocial, biological, and lifestyle mechanisms underlying Useful Field of View training (UFOVt).
  • To understand intervention transfer effects and guide future cognitive intervention designs.

Main Methods:

  • A double-blind randomized controlled trial involving 96 community-dwelling older adults.
  • Participants completed comprehensive assessments remotely via laptop and smartphone, including cognitive, psychosocial, health, and lifestyle measures.
  • A subsample underwent additional assessments including MRI and sleep monitoring, with training delivered over ten weeks.

Main Results:

  • Data collection occurred at baseline, post-test, and three-month follow-up, with daily assessments via smartphone.
  • Participants were randomized into a cognitive training group or an active control group.
  • Exploratory multilevel modeling will be used to analyze the data.

Conclusions:

  • EFIT incorporates novel features such as ecological momentary assessment and remote data collection.
  • The study evaluates mediators before, during, and after training, targeting one cognitive domain at a time.
  • The findings will enhance understanding of intervention transfer effects and inform future cognitive intervention strategies.