Related Experiment Video
Updated: May 29, 2025
08:53
Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery
Published on: April 16, 2019
7.6K
Centrifuge siliconization of primary container systems.
Brian Wong1, Kaitlin Wang1, Kavin Kowsari1
1Pharmaceutical Sciences and Clinical Supply, Merck & Co., Inc., Rahway, NJ 07065, United States.
Journal of Pharmaceutical Sciences
|February 1, 2025
Summary
A novel method uses common centrifuges to create uniform silicone oil layers in pre-filled syringes (PFS). This technique improves lubrication and overcomes limitations of current industrial silicone oil coating processes.
Area of Science:
- Pharmaceutical technology
- Materials science
Background:
- Pre-filled syringes (PFS) require silicone oil lubrication for plunger movement.
- Current silicone oil coating methods yield inhomogeneous layers and use specialized equipment.
Purpose of the Study:
- To develop an accessible and effective method for creating uniform silicone oil layers in PFS.
- To address the limitations of existing silicone oil coating technologies.
Main Methods:
- A new silicone oil coating technique utilizing standard centrifuge technology.
- Tunable layer thickness (400-1800 nm) achieved by adjusting centrifuge speed and temperature.
Main Results:
- Generation of uniform silicone oil layers in PFS.
- Demonstrated control over silicone layer thickness through process parameter adjustment.
- Overcame topographical defects like dimples common in traditional methods.
Conclusions:
- The developed centrifuge-based method offers a superior alternative for silicone oil coating in PFS.
- This accessible technique enhances syringe functionality and uniformity.
- Potential for wider adoption in research and non-commercial settings.
