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Prospective analysis on possible changes of cognitive functions in children on follow-up for brain tumor
Ilaria Liguoro1, Chiara Pilotto2, Francesco Tuniz3
1Division of Pediatrics, University Hospital of Udine, Piazzale Santa Maria Della Misericordia, 15, 33100, Udine, Italy. ilarialiguoro@gmail.com.
Insights
Children with brain tumors experience cognitive impairments, with surgery improving some functions but long-term decline possible. Regular neurocognitive evaluations are crucial for monitoring and early detection of difficulties in pediatric brain tumor patients.
Area of Science:
- Neuroscience
- Pediatric Oncology
- Cognitive Psychology
Background:
- Brain tumors in children often lead to significant cognitive deficits.
- Understanding the trajectory of cognitive function is vital for patient care and rehabilitation.
Purpose of the Study:
- To evaluate cognitive functioning in children with brain tumors before and after surgery.
- To assess cognitive changes at the end of all adjunctive treatments.
Main Methods:
- Prospective assessment of newly diagnosed children with primary brain tumors.
- Neurocognitive evaluations at three time points: pre-surgery (T0), early post-surgery (T1), and long-term post-treatment (T2).
- Assessment of language, memory, attention, executive functions, visual-constructional skills, sensorimotor skills, and intelligence quotient (IQ).
Main Results:
- At baseline, significant deficits were observed in narrative and visuo-spatial memory.
- Post-surgery, deficits persisted in narrative memory and visual-motor coordination, while attention and visual-constructional abilities improved.
- Long-term follow-up (T2) revealed persistent visuo-spatial deficits and a potential decline in median IQ.
Conclusions:
- Children with brain tumors exhibit neuropsychological impairments from diagnosis.
- Surgery can positively impact certain cognitive functions, but long-term cognitive decline is a concern.
- Regular neurocognitive evaluations are recommended for monitoring and early intervention in pediatric brain tumor patients.
Purpose:
This study was aimed at evaluating cognitive functioning in children with brain tumors before and after surgery and at the end of all adjunctive treatments.
Methods:
All newly diagnosed children with primary brain tumor were prospectively assessed. Neurocognitive evaluations were performed before surgery (T0), within 7-10 days from surgery (T1) and 18-24 months after the end of all treatments (T2). Language, memory, attention, executive functions, visual-constructional, and sensorimotor skills were evaluated at T0, T1, and T2, whereas intelligent quotient (IQ) was explored at T0 and T2.
Results:
Twenty-five patients (M:F = 15:10, mean age 10.9 ± 3.4 years) were enrolled between January 2019 and December 2022. At baseline, patients showed major deficits in narrative memory (6.6 ± 3.7, p < 0.001) and visuo-spatial memory (copy design tasks: general 6.8 ± 3.9, p < 0.001; specific 6.2 ± 3.3, p < 0.001; and motor 5.2 ± 3.2, p < 0.001). In the post-surgery phase (T1), significant deficits remained in narrative memory (6.2 ± 3.3, p < 0.001) and visual-motor coordination (copy design tasks: specific 5.9 ± 3.0, p < 0.001; motor 4.8 ± 4.3 p < 0.001), while attention and visual-constructional abilities significantly improved (p = 0.04 and p = 0.001 respectively). Nine out of 25 patients (36%) reached the T2 evaluation: persistency of deficits in the area of visuo-spatial processing and a possible decline in median IQ values in comparison to T0 evaluation (93 vs 100, p = 0.05) were shown.
Conclusions:
Children with brain tumors may present several neuropsychological impairments since diagnosis. Surgery may have a positive impact in relation to the recovery of some cognitive functions. However, cognitive decline may worsen over time. Baseline and periodic neurocognitive evaluations should be encouraged to indicate targets for cognitive monitoring, to early detect functional difficulties.
