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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

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Classifications of triple-negative breast cancer: insights and current therapeutic approaches

Ziqi Chen1,2, Yumeng Liu1,2, Minchuan Lyu1,2

  • 1Institute of Systems Medicine and Health Sciences, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, SAR, China.

Cell & Bioscience
|February 1, 2025
PubMed

Insights

Triple-negative breast cancer (TNBC) is aggressive and hard to treat due to its heterogeneity. Understanding TNBC subtypes is key to developing targeted therapies and improving patient survival rates.

Area of Science:

  • Oncology
  • Cancer Research

Background:

  • Triple-negative breast cancer (TNBC) lacks targeted therapy options due to absent hormone and HER2 receptors.
  • TNBC presents high recurrence and metastasis rates, leading to poorer prognoses.
  • Significant molecular and histopathological heterogeneity complicates effective treatment development.

Purpose of the Study:

  • To provide a comprehensive overview of TNBC subtypes and their distinct molecular profiles.
  • To highlight the limitations of current therapeutic strategies for TNBC.
  • To explore innovative biological approaches for targeted TNBC treatment.

Main Methods:

  • Review of existing literature on TNBC classification systems.
  • Analysis of proteomic, transcriptomic, and genomic data for subtype characterization.
  • Evaluation of current and emerging therapeutic strategies.

Main Results:

  • Detailed characterization of various TNBC subtypes based on established classification systems.
  • Identification of challenges posed by chemotherapy resistance in TNBC.
  • Exploration of novel molecular targets and biological pathways for therapy.

Conclusions:

  • Precise classification of TNBC subtypes is essential for personalized molecular therapy.
  • Overcoming treatment resistance and heterogeneity is critical for improving TNBC outcomes.
  • Advancing targeted therapeutic strategies is vital for enhancing survival in TNBC patients.
Keywords:
ClassificationNeoadjuvant therapySubtypeTriple-negative breast cancerTumor heterogeneity

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