Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Combined Effects of Drugs: Synergism

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...

Antimicrobial Proteins

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Rechargeable N-Halamine Hydrogel Paint Coating Based on Upcycled Sesame Meal Protein for Preventing Cross-Contamination on Food-Contact Surfaces.

Journal of food science·2026

Same author

An Immediate-Response Detection System for γ-Hydroxybutyrate to Enhance Personal Safety in Social Environments.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

An aryloxyphenol potentiates polymyxin against multidrug-resistant <i>Acinetobacter baumannii</i>.

Frontiers in cellular and infection microbiology·2026

Same author

Transcriptional and epigenetic regulation of autophagy: mechanisms, disease relevance and therapeutic opportunities.

Signal transduction and targeted therapy·2026

Same author

CRISPR-Cpf1-Mediated Gene-Editing System Based on a Single Bidirectional Promoter.

International journal of molecular sciences·2026

Same author

Repetitive transcranial magnetic stimulation suppresses glia-associated neuroinflammation and promotes peripheral nerve recovery in neuropathic pain.

Frontiers in immunology·2026

Search research articles

Related Experiment Video

Updated: May 29, 2025

Synthesis of Functionalized Magnetic Nanoparticles, Their Conjugation with the Siderophore Feroxamine and its Evaluation for Bacteria Detection

Synthesis of Functionalized Magnetic Nanoparticles, Their Conjugation with the Siderophore Feroxamine and its Evaluation for Bacteria Detection

Published on: June 16, 2020

Siderophore-Functionalized Nanodrug for Treating Antibiotic-Resistant Bacteria.

Siyoung Ha^1,2, Jinyeong Kim³, Hwi Won Seo^1,4

¹Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.

|February 2, 2025

Summary

A novel gold nanoparticle nanodrug (AuNP-NSC) effectively targets and eliminates multidrug-resistant Pseudomonas aeruginosa. This innovative approach shows promise for combating antimicrobial resistance and treating severe bacterial infections.

Keywords:

MDR N-heterocyclic carbenes drug resistant nanodrug siderophore

More Related Videos

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Published on: September 27, 2024

Author Spotlight: Quantifying Siderophores and Pyochelin for Infection Control

Author Spotlight: Quantifying Siderophores and Pyochelin for Infection Control

Published on: March 15, 2024

Related Experiment Videos

Last Updated: May 29, 2025

Synthesis of Functionalized Magnetic Nanoparticles, Their Conjugation with the Siderophore Feroxamine and its Evaluation for Bacteria Detection

Synthesis of Functionalized Magnetic Nanoparticles, Their Conjugation with the Siderophore Feroxamine and its Evaluation for Bacteria Detection

Published on: June 16, 2020

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Published on: September 27, 2024

Author Spotlight: Quantifying Siderophores and Pyochelin for Infection Control

Author Spotlight: Quantifying Siderophores and Pyochelin for Infection Control

Published on: March 15, 2024

Area of Science:

Nanotechnology
Antimicrobial Resistance
Bacterial Pathogenesis

Background:

Multidrug-resistant bacteria pose a significant global health threat.
Antimicrobial resistance necessitates novel therapeutic strategies.
Nanodrugs offer targeted delivery to overcome resistance mechanisms.

Purpose of the Study:

To develop and evaluate a siderophore-functionalized nanodrug (AuNP-NSC) for targeting multidrug-resistant bacteria.
To assess the efficacy of AuNP-NSC against Pseudomonas aeruginosa.
To investigate the potential of nanodrugs in combating antimicrobial resistance.

Main Methods:

A gold nanoparticle construct (AuNP-NSC) functionalized with siderophores and N-heterocyclic carbenes was synthesized.
Targeted delivery of AuNP-NSC into P. aeruginosa was achieved via ferric iron binding.
In vitro and in vivo studies were conducted using antibiotic-resistant P. aeruginosa models.

Main Results:

AuNP-NSC significantly inhibited P. aeruginosa proliferation, reducing bacterial counts by over 95%.
The nanodrug mitigated drug resistance in P. aeruginosa infections.
AuNP-NSC treatment reduced P. aeruginosa-induced skin lesions and prevented sepsis-related organ failure in mouse models.

Conclusions:

Siderophore-functionalized nanodrugs represent a promising therapeutic strategy against antibiotic-resistant bacterial infections.
AuNP-NSC demonstrates significant potential for managing drug-resistant pathogens like P. aeruginosa.
Nanodrugs can be engineered for targeted delivery, enhancing antimicrobial efficacy and reducing resistance.