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Related Experiment Video

Updated: May 29, 2025

Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation
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Does Schistosoma mansoni trigger colorectal cancer?

Sidhant Jain1

  • 1Institute for Globally Distributed Open Research and Education (IGDORE), India.

Molecular and Biochemical Parasitology
|February 2, 2025
PubMed
Summary

Schistosoma mansoni (Sm) infection may influence colorectal cancer (CRC) development through chronic inflammation, parasite antigens, and gut microbiota changes. Further studies are needed to confirm this link and its mechanisms.

Keywords:
CarcinogenesisColorectal cancerInflammationROSSchistosoma mansoniSoluble egg antigens

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Area of Science:

  • Parasitology
  • Oncology
  • Gastroenterology

Background:

  • Colorectal cancer (CRC) is a significant global health concern.
  • The role of Schistosoma mansoni (Sm) infection in CRC development is debated, with conflicting evidence.
  • Understanding potential links between parasitic infections and cancer is crucial for public health.

Purpose of the Study:

  • To examine the relationship between Schistosoma mansoni infection and colorectal cancer.
  • To propose potential mechanisms by which Sm infection might contribute to CRC induction and progression.
  • To highlight the need for further research to establish a definitive association.

Main Methods:

  • Review of existing clinical studies on Sm infection and CRC.
  • Proposal of hypothetical mechanisms linking Sm infection to CRC.
  • Identification of key factors: chronic inflammation, parasite antigens (SEAs), and gut microbiota alteration.

Main Results:

  • Clinical studies show inconsistent associations between Sm infection and CRC.
  • Plausible mechanisms include chronic inflammation, exposure to parasite antigens like SEAs, and dysbiosis of intestinal microbiota.
  • These factors may predispose individuals to CRC and influence its progression.

Conclusions:

  • Schistosoma mansoni infection is potentially linked to colorectal cancer development and progression.
  • Chronic inflammation, parasite-derived antigens, and altered gut microbiota are proposed contributing factors.
  • Extensive epidemiological, clinical, and pathological studies are required to confirm these findings.