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Related Concept Videos

Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

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Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
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Quercetin-loaded solid lipid nanoparticles for enhanced anti-helminthic activity.

Sunidhi Sharma1, Ruchika Thukral2, Lachhman Das Singla3

  • 1Department of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, Patiala 147004, Punjab, India.

International Journal of Pharmaceutics
|February 2, 2025
PubMed
Summary

This study developed quercetin-loaded solid lipid nanoparticles (SLN-Qt) to improve oral bioavailability and effectiveness. SLN-Qt significantly reduced parasitic infections in rats with no observed toxicity, offering a promising drug delivery strategy.

Keywords:
AlbendazoleAnthelminthic drugsPre-clinical trialQuercetinSolid lipid nanoparticlesSustained release

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Area of Science:

  • Pharmacology
  • Nanotechnology
  • Parasitology

Background:

  • Quercetin, a flavonoid, has anti-carcinogenic, anti-viral, and anti-inflammatory properties.
  • Poor oral bioavailability limits quercetin's therapeutic efficacy due to intestinal metabolism.
  • Lipid-based nanoparticles offer a strategy to enhance solubility and delivery of poorly soluble drugs.

Purpose of the Study:

  • To develop and characterize quercetin-loaded solid lipid nanoparticles (SLN-Qt) for improved oral administration.
  • To evaluate the in vitro drug release profile of SLN-Qt.
  • To assess the in vivo anti-helminthic efficacy and safety of SLN-Qt in infected rats.

Main Methods:

  • Fabrication and characterization of spherical, water-soluble solid lipid nanoparticles (SLN-Qt).
  • In vitro drug release studies at pH 6.4 and pH 7.4.
  • In vivo anti-helminthic efficacy testing in rats infected with various gastrointestinal helminths.
  • Assessment of liver histology and biochemical parameters for toxicity.

Main Results:

  • SLN-Qt exhibited a hydrodynamic size of 130.7 ± 42.0 nm with 79.75% drug entrapment efficiency.
  • Sustained drug release observed, with 37.5% at 24h (pH 6.4) and 93.7% over 6 days (pH 7.4).
  • SLN-Qt treatment (200 mg/Kg) significantly reduced parasite egg counts by 85.09% and showed no toxicity in rats.

Conclusions:

  • SLN-Qt enhances quercetin's solubility and bioavailability for oral delivery.
  • This formulation demonstrates significant efficacy against gastrointestinal helminths in vivo.
  • SLN-Qt represents a promising nanocarrier for treating parasitic infections and delivering poorly soluble drugs.