Next-generation electrochemical biosensors for acrylamide: Progress, challenges, and opportunities

Acrylamide is a hazardous substance present in heat-processed food products and industrial wastewater. It is carcinogenic and neurotoxic and therefore emphasises the importance of monitoring its levels and the need for sensitive and accurate detection techniques. Electrochemical biosensing has emerged as a potential analytical method for detecting acrylamide. This article provides a comprehensive overview of the most recent developments in electrochemical biosensing methods, including amperometric, potentiometric, and impedimetric biosensors for acrylamide detection. The creation and use of novel biorecognition components, such as enzymes, antibodies, and molecularly imprinted polymers that enhance the sensitivity and specificity of acrylamide monitoring, are given special attention. Incorporating nanomaterials such as carbon-based nanomaterials and metallic nanoparticles was investigated for its potential to improve the sensors' electrochemical characteristics and overall efficacy. The potential of electrochemical biosensors for acrylamide detection is further illustrated, showcasing their effectiveness in a range of matrices in different food products. This review aims to inform researchers about the latest technological developments, trends, and future directions in electrochemical biosensing for acrylamide detection. The study highlights the significance of ongoing research and cooperation in creating efficient biosensing systems to protect public health and the environment by thoroughly examining current technology and pointing out areas for improvement.