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Protective Effects of Korean Red Ginseng Against Oxidative Stress-Induced Damage in Human Hair

Seung-Won Jung1, Long-Quan Pi2, Jae Joon Jeon1

  • 1Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.

Annals of Dermatology
|February 2, 2025
PubMed
Abstract

Insights

Red ginseng extract (RGE) and its ginsenoside G-Rb1 protect against oxidative stress in hair follicles. This finding offers potential therapeutic strategies for hair loss and related disorders.

Area of Science:

  • Dermatology
  • Pharmacology
  • Cell Biology

Background:

  • Oxidative stress damages follicular keratinocytes (FKCs), contributing to hair loss disorders.
  • Understanding the molecular mechanisms of oxidative damage is crucial for developing hair growth treatments.

Purpose of the Study:

  • To investigate the protective effects of Red ginseng extract (RGE) and its ginsenosides against oxidative hair damage.
  • To evaluate the efficacy of RGE and G-Rb1 in an in vitro human hair follicle organ model.

Main Methods:

  • Utilized an in vitro organ model of human hair follicles.
  • Induced oxidative stress using hydrogen peroxide (H₂O₂) in FKCs.
  • Assessed the impact of RGE and ginsenosides on apoptosis, reactive oxygen species (ROS) production, and hair growth parameters.

Main Results:

  • RGE and G-Rb1 significantly reduced ROS production and apoptosis in FKCs.
  • Both RGE and G-Rb1 alleviated oxidative damage-induced inhibition of hair growth.
  • These compounds inhibited the anagen to telogen transition, modulating p53 and Bax/Bcl2 signaling pathways.

Conclusions:

  • Red ginseng extract and G-Rb1 demonstrate significant protective effects against oxidative damage in FKCs.
  • These findings suggest RGE and G-Rb1 can mitigate hair damage and influence hair cycle regulation.
  • Potential therapeutic applications for hair loss and oxidative stress-related hair conditions.
Keywords:
AlopeciaGinsenosidesHair follicleOxidative stressRed ginseng extract

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