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Updated: May 29, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Oxidative Coupling of Guanidines and Isocyanides Catalyzed by Nickel(II): Access to Imidazoline Derivatives with
Georgii A Gavrilov1, Tuan K Nguyen1, Svetlana A Katkova1
1Saint Petersburg State University, 7-9-11 Universitetskaya Nab., St., Petersburg, 199034, Russian Federation.
Abstract:
A novel and concise approach to rare 2,3,5-triamino-imidazole scaffolds via Ni-catalyzed coupling of alkylisocyanides and N,N'-diarylguanidines has been developed. This reaction features include mild conditions (thermal or visible light activation), a wide substrate scope, and high efficiency. The coupling proceeds through a NiII/NiIV catalytic cycle, involving two-electron aerobic oxidation and the sequential insertion of two isocyanide units into Ni-N bonds.Testing these compounds against pathogens of the ESKAPE panel showed their high activity with a minimum inhibitory concentration down to 0.38 μg/mL.
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