Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 9, 2026

A Method for Systematic Electrochemical and Electrophysiological Evaluation of Neural Recording Electrodes
09:27

A Method for Systematic Electrochemical and Electrophysiological Evaluation of Neural Recording Electrodes

Published on: March 4, 2014

Graphene-Based Microelectrodes with Reinforced Interfaces and Tunable Porous Structures for Improved Neural

Miheng Dong1,2, Junjun Yang2,3, Fangzheng Zhen2,3

  • 1Department of Materials Science and Engineering, Monash University, Clayton, Victoria 3800, Australia.

ACS Applied Materials & Interfaces
|February 3, 2025
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive Analysis and Prognostic Modeling of Epithelioid Trophoblastic Tumor.

Obstetrics and gynecology·2026
Same author

Protonation-Triggered Unlocking of Interlayer Carbon Nitride for Rapid Nanosheet Preparation.

Angewandte Chemie (International ed. in English)·2026
Same author

Saikosaponin A restores the IDO1-driven gut-testis kynurenine axis to alleviate oligozoospermia.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

Development of a Machine Learning‑Based Prognostic Model for Intermediate Trophoblastic Tumors: A Single-Center Study With Web-Based Tool Implementation.

JCO precision oncology·2026
Same author

Gut microbiota-derived Tryptophanol driven by N-Carbamylglutamate alleviates premature ovarian failure through inhibiting oxidative stress.

Journal of ovarian research·2026
Same author

Microwave digestion-ICP-MS coupled with molecular docking: unraveling elemental distribution and its correlation with glucose and fructose accumulation in 25 strawberry cultivars.

Food chemistry·2026

Graphene microelectrodes with tunable porous structures offer improved neural recording and stimulation. Optimized graphene electrodes demonstrate lower impedance and higher capacity than platinum, enhancing signal quality and implant longevity.

Area of Science:

  • Biomaterials Science
  • Neuroscience
  • Materials Engineering

Background:

  • Minimizing inflammatory responses in invasive neural implants is crucial for longevity.
  • Graphene microfibers offer a high electrochemical surface area (ESA)/geometrical surface area (GSA) ratio, suggesting potential for low impedance and high charge injection capacity (CIC).
  • Precise control over graphene's porous structure is key to optimizing its electrochemical performance but remains under-investigated.

Purpose of the Study:

  • To develop and characterize wet-spun graphene-based electrodes with tunable porous structures.
  • To optimize the electrochemical properties of reduced graphene oxide (rGO) by controlling pore size through sucrose concentration.
  • To evaluate the performance of these novel electrodes for neural recording and stimulation compared to conventional platinum microwires.
Keywords:
brain sciencegrapheneinvasive electrodeneural electrodesensing

More Related Videos

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording
09:58

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

Published on: February 12, 2020

Open-source Toolkit: Benchtop Carbon Fiber Microelectrode Array for Nerve Recording
07:50

Open-source Toolkit: Benchtop Carbon Fiber Microelectrode Array for Nerve Recording

Published on: October 29, 2021

Related Experiment Videos

Last Updated: Jun 9, 2026

A Method for Systematic Electrochemical and Electrophysiological Evaluation of Neural Recording Electrodes
09:27

A Method for Systematic Electrochemical and Electrophysiological Evaluation of Neural Recording Electrodes

Published on: March 4, 2014

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording
09:58

Fabrication of Ti3C2 MXene Microelectrode Arrays for In Vivo Neural Recording

Published on: February 12, 2020

Open-source Toolkit: Benchtop Carbon Fiber Microelectrode Array for Nerve Recording
07:50

Open-source Toolkit: Benchtop Carbon Fiber Microelectrode Array for Nerve Recording

Published on: October 29, 2021

Main Methods:

  • Graphene-based electrodes were fabricated using a wet-spinning technique.
  • Pore structure was tuned by varying sucrose concentrations in the coagulation bath.
  • Electrochemical properties (impedance, CIC, charge storage capacity - CSC) were measured.
  • Mechanical properties were assessed through tensile and insertion tests.
  • In vivo acute recordings from the auditory cortex and ex vivo recordings from hippocampal slices were performed.

Main Results:

  • Optimized rGO/sucrose ratios significantly reduced impedance and increased CIC and CSC compared to platinum microwires.
  • Electrodes exhibited sufficient tensile strength for 100% insertion success with minimal angle shift.
  • In vivo recordings showed improved signal-to-noise ratio (SNR) due to lower impedance.
  • Ex vivo recordings demonstrated high-fidelity neural recording and stimulation capabilities.

Conclusions:

  • Wet-spun graphene electrodes with controlled porosity offer superior electrochemical performance over platinum microwires.
  • These graphene electrodes are mechanically robust for precise implantation.
  • They show significant promise for advanced neural interfaces, improving both implant longevity and signal quality.