Hypopharyngeal Amyloidosis: A Rare Cause of Dysphagia

Amyloidosis localized to the head and neck most commonly affects the laryngo-tracheobronchial tree or tongue. It rarely affects the hypopharynx, with only 3 cases reported in literature. All of these cases describe females presenting with hypopharyngeal amyloid masses and associated multiple myeloma or monoclonal gammopathy of undetermined significance. They were treated with chemotherapy and CO₂ laser, respectively. In comparison, our case identifies a 69-year-old female, with a history of MALT lymphoma but no concurrent malignancy. She initially presented with dysphagia and was diagnosed with hypopharyngeal amyloidosis. After 532 nm potassium titanyl phosphate laser treatment, she ultimately felt improvement in her dysphagia. Laryngoscope, 135:2086-2088, 2025.