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Updated: May 29, 2025

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
New Ru(III) 2,6-Bis(2-Benzimidazolyl)Pyridine Complexes Bearing P-Sub-Benzyl Thiosemicarbazones Schiff Base:
Ashok K Singh1, Ravindra K Singh1, Kumud Pandav2
1Department of Chemistry, Faculty of Science, University of Lucknow, Babuganj, Hasanganj, Lucknow, 226007, Uttar Pradesh, India.
Abstract:
The six mononuclear Schiff's base Ru(III) complexes viz., [Ru(BZP)(LA)2].2NO3 (MRA), [Ru(BZP)(LB)2].2NO3 (MRB), [Ru(BZP))(LC)2].2NO3 (MRC), [Ru(BZP))(LD)2].2NO3 (MRD), [Ru(BZP)(LE)2].2NO3 (MRE) and [Ru(BZP)(LF)2].2NO3 (MRF), were synthesized using of (BZP=2,6-bis(2-benzimidazolyl)pyridine and p-sub-benzylthiosemicarbazones (BTS) [(Sub=4-NO2 (LA), 4-N(CH3)2 (LB), 4-Cl (LC), 4-OCH3 (LD), 4-OCH2Ph (LE), and 4-OH (LF)] as an ancillary ligands. The thiosemicarbazones ligands (LA-LF) were obtained by the condensation of p-substituted benzaldehyde and thiosemicarbazide. These complexes were characterized by elemental analysis, IR, ESR, ESI-MS, electronic absorption spectroscopy. The geometry was optimized by theoretical calculation using DFT and structure reveals that MRA-MRF adopt octahedral geometry. Further, the complexes were examined for anti-cancer against Leukemia cancer cell line K562 and shown significant responses to these cells. Moreover, DNA binding studies were conducted with all complexes MRA-MRF and the binding constant (Kb) were found i.e., 1.10×104, 1.54×104, 2.87×104, 1.67×104, 1.98×104 and 1.59×104, respectively. It was found that DNA binds in intercalation mode which is also validated by the docking studies.
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