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Efficacy and Safety of Tocilizumab in Polymyalgia Rheumatica: A Systematic Review and Meta-Analysis

Meha Sharma1, Siddharth Kumar Das2, Ritin Mohindra3

  • 1Department of Rheumatology, Center for Endocrinology Diabetes Arthritis and Rheumatism (CEDAR) Superspeciality Healthcare, New Delhi, India.

International Journal of Rheumatic Diseases
|February 3, 2025
PubMed
Abstract

Insights

Tocilizumab effectively treats polymyalgia rheumatica (PMR), significantly improving patient outcomes and allowing for reduced corticosteroid use. The drug is well-tolerated, with comparable adverse events to placebo in clinical trials.

Area of Science:

  • Rheumatology
  • Immunology
  • Pharmacology

Background:

  • Polymyalgia rheumatica (PMR) is a chronic inflammatory condition.
  • Current treatments often involve long-term corticosteroid use, associated with significant side effects.
  • A need exists for effective, steroid-sparing therapies in PMR management.

Conclusions:

  • Tocilizumab is an effective and well-tolerated treatment for polymyalgia rheumatica.
  • Tocilizumab demonstrates significant glucocorticoid-sparing properties in PMR management.
  • Further research may explore specific adverse event profiles in long-term use.
Keywords:
meta‐analysispolymyalgia rheumaticasafetytocilizumab

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