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Ascorbic acid in fetal rat brain.

C C Kratzing, J D Kelly, J E Kratzing

    Journal of Neurochemistry
    |May 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Ascorbic acid levels in fetal rat brains significantly increase during late gestation. Postnatal development shows a notable decrease in this crucial vitamin.

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    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Biochemistry

    Background:

    • Ascorbic acid (vitamin C) is vital for brain development.
    • Understanding its concentration dynamics during fetal development is crucial.

    Purpose of the Study:

    • To quantify ascorbic acid levels in the fetal rat brain during late gestation.
    • To observe changes in ascorbic acid concentration from late gestation through early postnatal life.

    Main Methods:

    • Tissue sampling from fetal rat brains at specific gestational days.
    • Quantification of ascorbic acid concentration using biochemical assays.

    Main Results:

    • Ascorbic acid concentration increased from 374 mg/g on day 15 to 710 mg/g on day 20 of gestation.

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  • Levels remained elevated until birth, followed by an 18% decrease after birth.

    • Conclusions:

    • Significant accumulation of ascorbic acid occurs in the late fetal rat brain.
    • A marked reduction in brain ascorbic acid is observed immediately after birth.