Novel Tapentadol Screen-Printed Carbon Sensor Integrated Copper Oxide Nanostructure.
Razan M Snari1, Zehbah A Al-Ahmed2, Arwa Alharbi1
1Department of Chemistry, Faculty of Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
ACS Omega
|February 3, 2025
Summary
Researchers developed novel copper oxide nanoparticle (CuONP) screen-printed electrodes (SPEs) for sensitive tapentadol (TAP) detection. This cost-effective sensor offers high accuracy in pharmaceutical and biological samples.
Area of Science:
- Electrochemistry
- Nanomaterials Science
- Analytical Chemistry
Background:
- Accurate quantification of tapentadol (TAP) is crucial for pharmaceutical quality control and clinical monitoring.
- Existing analytical methods may lack sensitivity, selectivity, or cost-effectiveness for routine analysis.
- Copper oxide nanoparticles (CuONPs) offer unique electrochemical properties for sensor development.
Purpose of the Study:
- To fabricate and evaluate planar screen-printed disposable sensors based on CuONPs (CuONPs/SPEs) for tapentadol determination.
- To assess the electroanalytical performance of CuONPs/SPEs in pharmaceutical products and biological fluids.
- To investigate the potential for simultaneous quantification of tapentadol and paracetamol.
Main Methods:
- Fabrication of screen-printed electrodes modified with copper oxide nanoparticles (CuONPs/SPEs).
- Voltammetric determination of tapentadol using the developed CuONPs/SPEs in a Britton-Robinson (BR) buffer.
- Electrochemical investigations and molecular orbital calculations to elucidate the oxidation mechanism.
- Validation of the sensor's performance, including linearity, limit of detection (LOD), reproducibility, and interference studies.
Main Results:
- CuONPs/SPEs demonstrated effective electrocatalytic activity for tapentadol oxidation at an anodic peak potential of 0.84 V (pH 5).
- The oxidation mechanism involves the transfer of two electrons and two protons from the tertiary amine group of tapentadol.
- A wide linear range (0.83–738 ng mL⁻¹) with a low LOD (0.24 ng mL⁻¹) was achieved for tapentadol.
- The sensors exhibited high reproducibility, a long lifetime (6 months), and minimal interference from common substances.
- Simultaneous quantification of tapentadol and paracetamol was successfully demonstrated.
- The CuONPs/SPEs were effectively applied to monitor tapentadol residues and in vitro dissolution studies.
Conclusions:
- The developed CuONPs/SPEs provide a sensitive, selective, and reproducible platform for tapentadol voltammetric determination.
- This disposable sensor technology holds promise for efficient quality control of pharmaceutical formulations and biological sample analysis.
- The ability to simultaneously detect tapentadol and paracetamol enhances its utility in complex sample matrices.
