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A Case Report of Anti-GD3 Antibody Positive Incomplete Miller-Fisher Syndrome With Pyramidal Tract Symptoms

Zhaojiao Li1, Jun Li1, Lingchun Liu1

  • 1Department of Neurology The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology Kunming China.

Clinical Case Reports
|February 3, 2025
PubMed

Insights

Incomplete Miller-Fisher syndrome (MFS) can present atypically. This case highlights anti-GD3 antibodies in a patient with incomplete MFS and pyramidal signs, suggesting their role in unusual MFS presentations.

Area of Science:

  • Neurology
  • Immunology
  • Autoimmune Disorders

Background:

  • Incomplete Miller-Fisher syndrome (MFS) is a rare neurological autoimmune disorder.
  • Atypical MFS cases often lack classic symptoms like ophthalmoplegia and areflexia.
  • Anti-GD3 antibodies are rarely associated with MFS.

Purpose of the Study:

  • To report a case of incomplete MFS with unusual clinical features.
  • To investigate the association of anti-GD3 antibodies in atypical MFS.
  • To highlight potential roles of anti-GD3 antibodies in MFS pathogenesis.

Main Methods:

  • Case report of a patient diagnosed with incomplete MFS.
  • Clinical assessment including neurological examination.
  • Serological testing for anti-GD3 antibodies.

Main Results:

  • The patient presented with incomplete MFS and pyramidal tract signs.
  • Positive anti-GD3 antibody results were detected.
  • Absence of typical MFS features such as extraocular muscle paralysis and areflexia.

Conclusions:

  • Anti-GD3 antibodies may be implicated in the pathogenesis of certain atypical MFS cases.
  • This finding broadens the understanding of MFS variants.
  • Clinicians should consider anti-GD3 antibody testing in suspected atypical MFS.
Keywords:
Miller‐Fisher syndromeanti‐GD3 antibodycase reportnovel coronavirus vaccinepyramidal tract symptom

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