Diagnostic challenges in SLIPPERS syndrome: Case report.

Area of Science:

• Neurology
• Neuroimmunology
• Radiology

Background:

• SLIPPERS (Supratentorial Lymphocytic Inflammation with Parenchymal Perivascular Enhancement Responsive to Steroids) is a rare supratentorial variant of CLIPPERS (Chronic Lymphocytic Inflammation with Ponsine Perivascular Enhancement Responsive to Steroids).
• SLIPPERS shares radiological and pathological features with CLIPPERS, raising questions about its classification as a distinct entity versus a manifestation of other conditions like vasculitis or infections.

Observation:

• A 26-year-old woman with no significant medical history presented with symptoms suggestive of SLIPPERS.
• Cranial MRI revealed T2 hyperintense lesions with characteristic linear-patchy enhancement patterns.
• Laboratory investigations excluded several differential diagnoses, supporting the diagnosis of SLIPPERS.

Findings:

• The patient was diagnosed with SLIPPERS syndrome based on clinical presentation and neuroimaging findings.
• Treatment with methylprednisolone was initiated, demonstrating responsiveness to steroid therapy.

Implications:

• SLIPPERS and CLIPPERS present diagnostic complexities requiring thorough investigation to prevent misdiagnosis.
• Accurate diagnosis and prompt initiation of appropriate treatment, such as corticosteroids, are crucial for managing these conditions.
• Careful follow-up is essential for patients diagnosed with SLIPPERS or CLIPPERS.