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Cancer Prevention02:59

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Related Experiment Video

Updated: May 29, 2025

Comet Assay as an Indirect Measure of Systemic Oxidative Stress
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The evaluation of the inflammatory status and systemic antioxidant-oxidant balance of women with breast cancer during

Joanna Grupińska1,2, Magdalena Budzyń1, Jakub Janowski3

  • 1Chair and Department of Medical Chemistry and Laboratory Medicine, Poznan University of Medical Sciences, Poznan, Poland.

Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology
|February 3, 2025
PubMed
Summary

Adjuvant chemotherapy causes systemic inflammation in breast cancer patients, indicated by increased high-sensitivity C-reactive protein (hs-CRP) and altered oxidative stress markers. These inflammatory changes can vary based on cancer characteristics and body composition.

Keywords:
adjuvant chemotherapybreast cancerglutathione peroxidasehigh sensitivity C-reactive proteininflammationmalondialdehydeoxidative stresstotal antioxidant capacity

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Area of Science:

  • Oncology
  • Biochemistry
  • Inflammation Research

Background:

  • Chemotherapy can induce systemic inflammation, necessitating reliable monitoring markers.
  • High-sensitivity C-reactive protein (hs-CRP) and oxidative stress markers are investigated for inflammation monitoring during cancer treatment.
  • Breast cancer patients undergoing chemotherapy are susceptible to inflammatory changes.

Purpose of the Study:

  • To analyze changes in hs-CRP and oxidative stress markers (malondialdehyde, glutathione peroxidase activity, total antioxidant capacity) during adjuvant chemotherapy in breast cancer patients.
  • To investigate the relationship between these markers and clinicopathological/anthropometric features.
  • To assess the impact of adjuvant chemotherapy on systemic inflammation and oxidative stress.

Main Methods:

  • Study included 90 women with breast cancer.
  • Blood samples were collected before and after two cycles of adjuvant chemotherapy.
  • Concentrations of hs-CRP, MDA, GPx activity, and TAC were measured.

Main Results:

  • Adjuvant chemotherapy significantly increased hs-CRP levels in the overall patient group.
  • Elevated hs-CRP was particularly noted in patients with specific tumor characteristics (e.g., hormone receptor-negative, no lymph node metastasis, smaller tumors, lower TNM stage).
  • Significant decrease in GPx activity was observed, especially in patients with larger/advanced tumors, and those with abnormal BMI/body fat. TAC and MDA levels remained unchanged.

Conclusions:

  • Adjuvant chemotherapy induces systemic inflammation in breast cancer patients, evidenced by increased hs-CRP and altered oxidative stress markers.
  • The intensity of inflammation during chemotherapy may be influenced by breast cancer specifics and patient body composition.
  • hs-CRP and GPx activity serve as potential indicators of treatment-related inflammation in breast cancer.