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Perindopril-Induced Collagenous Colitis: Case Report and Literature Review
Eddy Fares1, Weam El Hajj1, Stéphane Nahon1
1Department of Gastroenterology, Intercommunal Hospital Center Le Raincy Montfermeil, Montfermeil, France.
Insights
This study details the first reported instance of collagenous colitis linked to perindopril medication. The patient
Area of Science:
- Gastroenterology
- Pharmacology
- Histopathology
Background:
- Collagenous colitis is a rare form of microscopic colitis.
- Drug-induced colitis is an underdiagnosed condition.
- Perindopril is an angiotensin-converting enzyme inhibitor used for hypertension.
Abstract:
We report the first case of collagenous colitis attributed to perindopril use, in a 90-year-old woman. The patient developed diarrhea with hypokalemia, 3 weeks after perindopril was introduced in her medications for uncontrolled hypertension. Significant thickening of the basal epithelial membrane (up to 80 μm) was found on random colon biopsies. Diarrhea resolved within 3 days after perindopril withdrawal. Four months later, left colon biopsies revealed a normalization of the basal membrane thickness. The intrinsic imputability of perindopril as the causative agent of microscopic colitis is considered to be reasonable by the French accountability technique. There was no rechallenge test conducted.
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