Assessment of Immunological, Skeletal, and Thyroid Function Abnormalities in Paediatric Morphoea.

Area of Science:

• Dermatology
• Pediatrics
• Immunology
• Endocrinology

Background:

• Morphoea is a sclerosing skin disorder with potential systemic implications in children.
• Paediatric morphoea is linked to autoimmune diseases, bone deformities, and systemic issues.
• Limited research exists on immunological, skeletal, and thyroid abnormalities in paediatric morphoea.

Purpose of the Study:

• To investigate immunological, skeletal, and thyroid function abnormalities in children with morphoea.

Main Methods:

• A cross-sectional study of 42 paediatric morphoea patients.
• Involved detailed history, clinical examination, and investigations including blood counts, IgE, ANA, TFTs, anti-TPO antibodies, and radiology.
• Study period: January 2021 to March 2023.

Main Results:

• Anemia (14.28%), elevated serum IgE (33.33%), and raised anti-thyroid peroxidase (33.33%) were observed.
• Thyroid stimulating hormone was elevated in 11.9% of patients.
• Brain MRI revealed abnormalities in three patients.

Conclusions:

• Paediatric morphoea can present with diverse immunological, osteoarticular, and neurological issues.
• The study underscores the multi-system involvement in paediatric morphoea.
• Further research and trials are needed for evidence-based treatment.