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An optical coherence tomography study of a photoactive Pt(iv) prodrug in oesophageal tissue
Huayun Shi1,2,3, Muktesh Mohan4,5, Kanwarpal Singh4,5,6
1Department of Chemistry, University of Warwick Coventry CV4 7AL UK Huayun.Shi@xmu.edu.cn p.j.sadler@warwick.ac.uk.
Abstract:
Photoactive diazido Pt(iv) complexes display in vivo anticancer efficacy towards oesophageal tumours, a worldwide common cancer. Here we explore the use of optical coherence tomography (OCT) as a new method for detecting tissue penetration and damage produced by the photoactivatable anticancer complex trans,trans,trans-[Pt(pyridine)2(N3)2(OH)2] (FM190). Dehydration of the sample and a change in refractive index were observed for swine oesophageal tissue treated with FM190 and blue laser light (445 nm) using an OCT system. In contrast, tissues treated with FM190 or laser light alone showed no apparent damage.
Insights
Photoactive platinum(IV) complexes show promise for esophageal cancer treatment. Optical coherence tomography (OCT) effectively detected tissue damage from a novel platinum complex (FM190) activated by blue laser light.
Area of Science:
- Biomedical Optics
- Cancer Therapeutics
- Materials Science
Background:
- Photoactive platinum(IV) complexes demonstrate in vivo anticancer activity against esophageal tumors.
- Esophageal cancer remains a significant global health challenge.
- Developing targeted therapies and effective monitoring methods is crucial.
Purpose of the Study:
- To investigate optical coherence tomography (OCT) as a method for detecting tissue penetration and damage.
- To evaluate the effects of a photoactivatable platinum(IV) complex, FM190, on esophageal tissue.
- To assess the combined effect of FM190 and blue laser light on tissue.
Main Methods:
- Utilized an optical coherence tomography (OCT) system to image swine esophageal tissue.
- Treated tissue samples with the photoactivatable platinum(IV) complex FM190.
- Exposed treated tissue to blue laser light (445 nm).
- Analyzed OCT images for signs of tissue dehydration and changes in refractive index.
Main Results:
- OCT detected dehydration and refractive index changes in swine esophageal tissue treated with FM190 and blue laser light.
- Tissue treated with FM190 alone or blue laser light alone showed no significant damage.
- FM190 requires photoactivation by blue laser light to induce observable tissue changes.
Conclusions:
- Optical coherence tomography (OCT) is a viable tool for monitoring the effects of photoactivatable anticancer agents in tissues.
- The platinum(IV) complex FM190, when activated by blue light, causes localized tissue damage.
- This study highlights a potential strategy for targeted cancer therapy and real-time monitoring.
