Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Cell-Matrix Interactions

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Regular Aerobic Exercise Can Effectively Ameliorate the Skeletal Muscle and Mitochondrial Function Impairments Caused by <i>bves</i> Deficiency in Zebrafish.

International journal of molecular sciences·2026

Same author

Regular exercise improves cardiac dysfunction in Drosophila by inhibiting excessive mitochondrial fission through RalA.

Biochimica et biophysica acta. Molecular basis of disease·2026

Same author

Engineering Silk Fibroin-Based Biomaterials for Neural Repair.

Advanced materials (Deerfield Beach, Fla.)·2026

Same author

Integrative Multiomics Analysis Reveals Tumor-Associated Macrophage Heterogeneity and a Prognostic Signature in Gastric Cancer.

Human mutation·2026

Same author

Use of an Artificial Intelligence Algorithm to Increase Productivity in Implantable Loop Recorder Monitoring: A Multicentre Observational Study.

Cureus·2026

Same author

Effect of cerebellar vermis intermittent theta-burst stimulation on balance function in frail older adults: a randomized controlled trial.

BMC geriatrics·2026

Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026

Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026

Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026

Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026

Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026

Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 29, 2025

Cell-cell Fusion of Genome Edited Cell Lines for Perturbation of Cellular Structure and Function

Cell-cell Fusion of Genome Edited Cell Lines for Perturbation of Cellular Structure and Function

Published on: December 7, 2019

Mapping cell-cell fusion at single-cell resolution.

Andrea L Gardner¹, Lan Zheng¹, Kennedy Howland¹

¹Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.

Biorxiv : the Preprint Server for Biology

|February 3, 2025

Summary

This summary is machine-generated.

Researchers developed ClonMapper Duo (CMDuo) to track cancer cell fusion. This tool reveals how cell fusion drives tumor evolution and distinct cancer cell states, aiding in understanding disease progression.

More Related Videos

A Faster, High Resolution, mtPA-GFP-based Mitochondrial Fusion Assay Acquiring Kinetic Data of Multiple Cells in Parallel Using Confocal Microscopy

A Faster, High Resolution, mtPA-GFP-based Mitochondrial Fusion Assay Acquiring Kinetic Data of Multiple Cells in Parallel Using Confocal Microscopy

Published on: July 20, 2012

A Cre-Lox P Recombination Approach for the Detection of Cell Fusion In Vivo

A Cre-Lox P Recombination Approach for the Detection of Cell Fusion In Vivo

Published on: January 4, 2012

Related Experiment Videos

Last Updated: May 29, 2025

Cell-cell Fusion of Genome Edited Cell Lines for Perturbation of Cellular Structure and Function

Cell-cell Fusion of Genome Edited Cell Lines for Perturbation of Cellular Structure and Function

Published on: December 7, 2019

A Faster, High Resolution, mtPA-GFP-based Mitochondrial Fusion Assay Acquiring Kinetic Data of Multiple Cells in Parallel Using Confocal Microscopy

A Faster, High Resolution, mtPA-GFP-based Mitochondrial Fusion Assay Acquiring Kinetic Data of Multiple Cells in Parallel Using Confocal Microscopy

Published on: July 20, 2012

A Cre-Lox P Recombination Approach for the Detection of Cell Fusion In Vivo

A Cre-Lox P Recombination Approach for the Detection of Cell Fusion In Vivo

Published on: January 4, 2012

Area of Science:

Cell biology
Cancer research
Genomics

Background:

Cell-cell fusion is crucial for normal human development and physiological processes.
Cancer cell fusion can lead to genomic instability, driving tumor evolution and potentially impacting treatment resistance.
Studying cancer cell fusion is challenging due to a lack of experimental systems for tracking individual fusion events.

Purpose of the Study:

To develop a novel molecular toolkit for mapping the origins and outcomes of individual cell fusion events in cancer.
To investigate the role of cell-cell fusion in cancer progression and treatment response.
To analyze transcriptomic changes and cellular states resulting from cancer cell fusion.

Main Methods:

Development of ClonMapper Duo (CMDuo), a molecular toolkit utilizing reporter expression and engineered nucleotide barcodes.
Application of CMDuo to identify and track cell fusion events within tumor cell populations.
Utilizing single-cell RNA sequencing (scRNA-seq) to analyze indexed barcodes and map parental cells and fusion progeny.

Main Results:

CMDuo successfully identified and mapped individual cell fusion events in a high-throughput manner.
In triple-negative breast cancer cells, CMDuo uncovered subclonal transcriptomic hybridization.
Distinct cell states arising directly from homotypic cell-cell fusion were identified.

Conclusions:

ClonMapper Duo (CMDuo) provides a powerful platform for studying cell-cell fusion in high-throughput single-cell data.
CMDuo enables detailed analysis of the consequences of cell fusion in disease progression and therapeutic response.
This toolkit facilitates a deeper understanding of how cancer cell fusion contributes to tumor heterogeneity and evolution.