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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: May 29, 2025

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model

Published on: September 11, 2020

Low Field Magnetic Resonance Imaging to Detect Acute Kidney Injury.

Shun Kishimoto^1,2,3, Kazumasa Horie³, Nallathamby Devasahayam³

¹Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Biorxiv : the Preprint Server for Biology

|February 3, 2025

Summary

This summary is machine-generated.

Electron Paramagnetic Resonance (EPR) oximetry non-invasively assessed kidney oxygen levels in mice with kidney injury. This technique accurately mapped oxygen distribution, unlike urine oximetry, offering a promising tool for renal research.

Keywords:

Acute Kidney Injury EPR Oximetry Renal Oxygenation

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Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Published on: March 11, 2016

Area of Science:

Nephrology
Biomedical Imaging
Physiology

Background:

Renal oxygenation is critical for kidney function; disruptions cause hypoxia and exacerbate kidney injury.
Current methods for assessing renal oxygenation are limited, lacking sensitivity or requiring invasive procedures.
There is a need for advanced, non-invasive techniques to monitor kidney oxygen levels, especially in disease states.

Purpose of the Study:

To evaluate Electron Paramagnetic Resonance (EPR)-based oxygen imaging as a non-invasive method for assessing kidney oxygenation.
To assess kidney oxygen levels in a mouse model of cyclophosphamide-induced kidney injury.
To compare EPR oximetry with urine pO2 measurements as a surrogate marker for renal oxygenation.

Main Methods:

Utilized EPR oximetry with the paramagnetic tracer Ox071 to image kidney oxygen levels in mice.
Induced kidney injury using cyclophosphamide in the study cohort.
Measured urine pO2 to evaluate its correlation with kidney oxygenation.

Main Results:

EPR oximetry accurately measured kidney oxygen distribution and revealed a temporary increase in pO2 post-injury.
Urine oximetry did not reliably reflect the dynamic changes in kidney oxygenation.
EPR oximetry provided high-resolution spatial mapping of oxygen levels within the kidney.

Conclusions:

EPR oximetry is a promising, non-invasive tool for monitoring renal oxygenation with high-resolution spatial mapping.
This technique enables detailed understanding of hypoxia's impact on renal tissue and supports longitudinal assessment.
EPR oximetry holds potential for advancing the study of renal pathophysiology and therapeutic development.