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Updated: May 29, 2025

Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment
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Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment

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Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases

Fengjuan Lin1, Huiyu Luo1, Jiexian Wang1

  • 1Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, National Medical Products Administration (NMPA) Key Laboratory for Safety Evaluation of Cosmetics, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.

Frontiers in Immunology
|February 3, 2025
PubMed

Insights

Macrophage-derived extracellular vesicles (M-EVs) are key in cell communication and disease. This review explores M-EV functions in chronic diseases and their therapeutic potential.

Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • Macrophages are vital innate immune cells involved in tissue homeostasis and disease.
  • Extracellular vesicles (EVs) mediate intercellular communication by transferring molecular cargo.
  • Macrophage-derived EVs (M-EVs) are increasingly recognized for their roles in various pathologies.

Purpose of the Study:

  • To review the biological functions and mechanisms of M-EVs in chronic non-communicable diseases.
  • To summarize the potential of M-EVs as biomarkers and therapeutic agents.
  • To explore M-EVs as drug delivery vehicles.

Main Methods:

  • Literature review of studies on M-EVs and their contents.
  • Analysis of M-EV roles in cardiovascular, metabolic, cancer, inflammatory, and bone diseases.
  • Assessment of M-EV applications in disease treatment and drug delivery.

Main Results:

  • M-EVs and their molecular cargo (miRNAs, mRNA, proteins) significantly influence disease pathogenesis.
  • M-EVs demonstrate potential as diagnostic biomarkers for various chronic conditions.
  • M-EVs show promise as targeted drug delivery systems.

Conclusions:

  • M-EVs are crucial mediators in chronic non-communicable diseases.
  • M-EVs hold significant potential for therapeutic applications and drug delivery strategies.
  • Further research into M-EVs could unlock novel treatment avenues for complex diseases.
Keywords:
biological functionschronic non-communicable diseasesdrug delivery systemsexosomesmacrophage-derived extracellular vesicles

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