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Evaluation of parameters predicting in-hospital mortality and septic embolisms in patients with infective

Tuba Tatlı Kış1, Mehmet Kış2, Tuncay Güzel3

  • 1Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Izmir Suat Seren Chest Diseases and Surgery Training and Research Hospital, Izmir, Turkey.

Postepy W Kardiologii Interwencyjnej = Advances in Interventional Cardiology
|February 3, 2025
PubMed

Insights

Predictive factors for septic embolism and mortality in infective endocarditis (IE) include vegetation size, high D-dimer, and low serum albumin. Identifying these can improve outcomes for IE patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Infective endocarditis (IE) is a serious cardiac infection with increasing incidence due to medical device use.
  • High morbidity and mortality rates persist despite modern treatments, with septic embolism being a major complication.

Purpose of the Study:

  • To identify predictive parameters for in-hospital mortality and septic embolism in patients diagnosed with infective endocarditis.
  • To enhance clinical decision-making and patient outcomes in IE management.

Main Methods:

  • Retrospective cohort study involving 64 patients with infective endocarditis.
  • Patients were categorized based on septic embolism or mortality.
  • Multivariable regression and ROC analysis were employed to identify significant predictors.

Main Results:

  • Vegetation size, aortic and mitral valve vegetation, serum albumin, and D-dimer levels were identified as independent predictors.
  • Specifically, larger vegetation size and elevated D-dimer correlated with increased risk.
  • Lower serum albumin levels were associated with higher mortality and embolism risk.

Conclusions:

  • Vegetation size, elevated D-dimer levels, and low serum albumin are significant predictors of in-hospital mortality and septic embolism in IE patients.
  • These findings can aid in risk stratification and early intervention strategies for infective endocarditis.
Abstract

Keywords:
Infective endocarditismortalityseptic embolism

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