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Relationship between uric acid to HDL ratio and extent and severity of coronary artery disease
Mehmet Yaman1, Ali Y Kilinc2, Fatih Öztürk1
1Cardiology Department, Echomar Hospital, Zonguldak, Turkey.
Insights
The uric acid to high-density lipoprotein (HDL) ratio (UHR) is significantly higher in patients with coronary artery disease (CAD). This easy-to-use UHR marker can help predict the presence and severity of CAD before invasive procedures.
Area of Science:
- Cardiology
- Biochemistry
- Inflammation research
Background:
- Coronary artery disease (CAD) is a leading global cause of mortality, primarily driven by atherosclerosis, a chronic inflammatory process.
- Assessing the extent and severity of CAD typically involves scoring systems like SYNTAX and Gensini.
- The uric acid to high-density lipoprotein (HDL) ratio (UHR) is recognized as a marker that elevates during inflammatory conditions.
Purpose of the Study:
- To determine the association between the UHR and the extent and severity of CAD.
- To investigate the correlation of UHR with established CAD scoring systems, specifically SYNTAX and Gensini.
Main Methods:
- A study cohort of 894 patients undergoing angiography was analyzed.
- Patients were categorized into a patient group (n=612) with critical coronary stenosis and a control group (n=282) without stenosis.
- Laboratory parameters, including uric acid and HDL levels, were compared, and the relationship between UHR and SYNTAX/Gensini scores was examined.
Main Results:
- Patients with CAD exhibited significantly higher uric acid levels and UHR compared to the control group (p < 0.01 for both).
- UHR demonstrated a significant correlation with both the SYNTAX and Gensini scoring systems.
- Receiver Operating Characteristic (ROC) curve analysis indicated that a UHR cut-off value of 0.1567 moderately predicted CAD (AUC = 0.669), with 61.1% sensitivity and 38.7% specificity.
Conclusions:
- The UHR serves as a readily accessible biomarker for predicting the presence, severity, and extent of coronary artery disease.
- UHR can be utilized as a pre-invasive assessment tool to aid in the evaluation of CAD.
Introduction:
Coronary artery disease (CAD) is common worldwide and is a significant cause of morbidity and mortality. CAD is a chronic and inflammatory disease mainly caused by atherosclerosis. SYNTAX and Gensini scoring systems are used to evaluate CAD extent and severity. Uric acid to high-density lipoprotein (HDL) ratio (UHR) increases in inflammatory conditions.
Aim:
To investigate the relationship between UHR and the extent and severity of CAD and its correlation with SYNTAX and Gensini scoring systems.
Material And Methods:
894 patients who underwent angiography were included in the study. 612 participants with critical coronary stenosis were designated as the patient group, and 282 participants without stenosis were designated as the control group. Characteristic features and laboratory parameters of the groups were compared. The relationship between the SYNTAX and Gensini scores of the patient group and UHR was analyzed.
Results:
Baseline characteristics and laboratory parameters were similar in both groups, except for uric acid and UHR levels. Both uric acid levels (7.58 ±2.55 mg/dl vs. 5.71 ±1.46 mg/dl, p < 0.01) and UHR (0.2016 ±0.094 vs. 0.1461 ±0.05, p < 0.01) were significantly higher in the patient group. UHR levels were found to be correlated significantly with both scoring systems. In the ROC curve analysis the UHR cut-off value of 0.1567 was able to predict CAD moderately (AUC = 0.669 (0.634-0.704), sensitivity 61.1%, specificity 38.7%).
Conclusions:
UHR is an easy-to-use parameter that can be used before invasive evaluation to predict the presence, severity, and extent of CAD.
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