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Sino-aortic denervation in the monkey.

K G Cornish, J P Gilmore

The Journal of Physiology

|March 1, 1985

Summary

This summary is machine-generated.

Denerving sino-aortic baroreceptors in monkeys did not significantly increase systemic blood pressure in their home cages. This suggests baroreceptor denervation has limited impact on blood pressure regulation in naturalistic settings.

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Behavioral Assessment of Manual Dexterity in Non-Human Primates

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Published on: November 11, 2011

Area of Science:

Cardiovascular Physiology
Neuroscience

Background:

Baroreceptors in the aortic arch and carotid sinuses are crucial for regulating blood pressure.
Understanding the precise role of these baroreceptors is essential for managing hypertension.

Purpose of the Study:

To investigate the effect of sino-aortic baroreceptor denervation on systemic blood pressure in a non-human primate model.
To determine if baroreceptor denervation leads to sustained hypertension under different environmental conditions.

Main Methods:

Eleven monkeys underwent sequential surgeries to denervate the aortic arch and carotid sinuses.
Blood pressure and pulse rate were monitored post-surgery in home cages and laboratory settings.
Baroreceptor function was confirmed by assessing heart rate response to blood pressure changes and the Bezold-Jarisch reflex.

Main Results:

Baroreceptor denervation significantly increased blood pressure when monkeys were restrained in laboratory chairs.
However, blood pressure remained not significantly elevated in denervated monkeys within their home cages.
The integrity of the vagus nerve was confirmed through the Bezold-Jarisch reflex.

Conclusions:

Sino-aortic baroreceptor denervation does not result in a significant increase in systemic blood pressure in a naturalistic home cage environment.
Environmental context and restraint may influence the observed effects of baroreceptor denervation on blood pressure.