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Complete blood count in neonatal Intensive care Unit (NICU): Performance comparison between POCT Sight OLO® and

Francesca Nencini¹, Alessandro Bonari¹, Sara Ciullini Mannurita¹

¹General Laboratory, Careggi University Hospital, Florence, Italy.

Practical Laboratory Medicine

|February 3, 2025

Abstract

Background And Aims:

The use of a POCT (Point Of Care Test) could help in reducing the impact of pre-analytical errors in particular in challenging newborn samples.The study purpose is to compare the POCT Sight OLO® hematology analyzer, validated for >3 months patients, with the reference system Sysmex XN-9100™ in Neonatal Intensive Care Unit (NICU).

Material And Methods:

The two analyzers were compared through Passing-Bablok regression analysis and Bland-Altman plot.

Results:

We analyzed 65 blood samples, in detail 38 from adults and 27 from newborns.The regression analysis results performed in the newborn and adult patients showed a good agreement between the two instruments. The evaluation of the Bland-Altman plots showed comparable values of bias <10 % for the most of parameters.The evaluation of sample flags for the presence of distributional and morphological abnormalities showed a partial accordance between the two approaches, but the POCT exhibited good performance compared to the final report revised by the laboratory specialist.

Conclusions:

The comparison of the two instruments demonstrated that they provide comparable blood counts, also in patients aged <3 months. The POCT allows having reliable analytical data and faster turning around time, particularly useful in NICU.

Keywords:

Complete blood count Hematology analyzer Newborn POCT Performance comparison

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