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Related Experiment Video

Updated: May 29, 2025

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Advancements in the Developmental Zebrafish Model for Predictive Human Toxicology.

Mackenzie L Morshead1, Robyn L Tanguay1

  • 1Sinnhuber Aquatic Research Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University 28645 East Highway 34, Corvallis, OR 97331, USA.

Current Opinion in Toxicology
|February 3, 2025
PubMed
Summary
This summary is machine-generated.

Early life stage zebrafish offer a powerful alternative to mammalian testing for rapid chemical hazard assessment. Their use in high-throughput screening generates valuable data for predictive toxicology and QSAR modeling.

Keywords:
High throughputPBPKQSARTranscriptomicsTranslation

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Area of Science:

  • * Toxicology and Ecotoxicology
  • * Vertebrate Model Systems
  • * Predictive Toxicology

Background:

  • * Mammalian testing for chemical hazard assessment is time-consuming and ethically challenging.
  • * There is a critical need for rapid, reliable methods to assess chemical toxicity.
  • * Early life stage zebrafish present a promising vertebrate model for toxicity testing.

Purpose of the Study:

  • * To review the advancements and challenges of using early life stage zebrafish in predictive human toxicology.
  • * To highlight the suitability of zebrafish for high-throughput developmental toxicity testing.
  • * To discuss the value of zebrafish data in QSAR and dose modeling.

Main Methods:

  • * Review of current literature on zebrafish developmental toxicity testing.
  • * Analysis of zebrafish model advantages for various study types (microbiome, transgenerational, etc.).
  • * Evaluation of data utility for quantitative structure-activity relationship (QSAR) and dose modeling.

Main Results:

  • * Zebrafish are highly amenable to high-throughput screening for developmental toxicity.
  • * They offer advantages for complex studies like microbiome and transgenerational research.
  • * Data from zebrafish studies are valuable for predictive hazard assessment and QSAR modeling.

Conclusions:

  • * Early life stage zebrafish are a leading model for reducing mammalian testing in chemical hazard assessment.
  • * Their utility extends to complex toxicological investigations and data-driven predictive modeling.
  • * Continued advancements are crucial for optimizing zebrafish use in human toxicology.