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Rapid Evaluation of Toxicity of Chemical Compounds Using Zebrafish Embryos
Published on: August 25, 2019
10.6K
Advancements in the Developmental Zebrafish Model for Predictive Human Toxicology
Mackenzie L Morshead1, Robyn L Tanguay1
1Sinnhuber Aquatic Research Laboratory, Department of Environmental and Molecular Toxicology, Oregon State University 28645 East Highway 34, Corvallis, OR 97331, USA.
Current Opinion in Toxicology
|February 3, 2025
Summary
Early life stage zebrafish offer a powerful alternative to mammalian testing for rapid chemical hazard assessment. Their use in high-throughput screening generates valuable data for predictive toxicology and QSAR modeling.
Area of Science:
- * Toxicology and Ecotoxicology
- * Vertebrate Model Systems
- * Predictive Toxicology
Background:
- * Mammalian testing for chemical hazard assessment is time-consuming and ethically challenging.
- * There is a critical need for rapid, reliable methods to assess chemical toxicity.
- * Early life stage zebrafish present a promising vertebrate model for toxicity testing.
Purpose of the Study:
- * To review the advancements and challenges of using early life stage zebrafish in predictive human toxicology.
- * To highlight the suitability of zebrafish for high-throughput developmental toxicity testing.
- * To discuss the value of zebrafish data in QSAR and dose modeling.
Main Methods:
- * Review of current literature on zebrafish developmental toxicity testing.
- * Analysis of zebrafish model advantages for various study types (microbiome, transgenerational, etc.).
- * Evaluation of data utility for quantitative structure-activity relationship (QSAR) and dose modeling.
Main Results:
- * Zebrafish are highly amenable to high-throughput screening for developmental toxicity.
- * They offer advantages for complex studies like microbiome and transgenerational research.
- * Data from zebrafish studies are valuable for predictive hazard assessment and QSAR modeling.
Conclusions:
- * Early life stage zebrafish are a leading model for reducing mammalian testing in chemical hazard assessment.
- * Their utility extends to complex toxicological investigations and data-driven predictive modeling.
- * Continued advancements are crucial for optimizing zebrafish use in human toxicology.
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