Domain-Specific Memory Impairments in Bipolar Mania: Insights from a Tertiary Care Hospital

Cognitive deficits in bipolar affective disorder (BPAD), particularly during manic episodes, are well-documented. However, research on domain-specific memory impairments in bipolar mania is limited, especially in the Indian subcontinent. This study aimed to assess memory impairments in individuals with bipolar disorder using the Postgraduate Institute Memory (PGI-Memory) scale and to highlight domain-specific deficits compared to healthy controls.

This cross-sectional study was conducted at a tertiary care center in North India. Twenty subjects diagnosed with bipolar mania and 20 age, sex, and education-matched healthy controls between the ages of 18 and 40 were recruited. Memory functions were assessed using the PGI-Memory scale. Mental control and working memory were also evaluated.

Both groups were matched in terms of age, sex, and education. Individuals with bipolar disorder demonstrated significant deficits in various memory domains, including immediate (d = 1.47), recent (d = 0.93), remote (d = 1.58), long-term (d = 2.37), and associative memory (similar pairs: d = 1.4, dissimilar pairs: d = 1.84,), as well as in visual reproduction (d = 2.3) and recognition tasks (d = 1.54). In contrast, their working memory performance was comparable to that of the control group. The largest deficits were observed in long-term memory, visual reproduction, and associative memory.

Bipolar mania is associated with widespread memory impairments, particularly in long-term and associative memory, which may contribute to difficulties in emotional regulation and daily functioning. These findings emphasize the importance of considering memory impairments in the diagnosis and management of BPAD. Further studies are required to investigate the neurobiological foundations of these impairments and to develop specific interventions.