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Related Experiment Video

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Alpha synuclein and inflammaging.

Geneviève L Putnam1, Robert W Maitta2,1

  • 1Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Heliyon
|February 3, 2025
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Summary

Alpha-synuclein (α-syn) protein interacts with inflammasomes during aging, potentially linking aging, chronic inflammation, and Parkinson's disease (PD). This review explores the connection between α-syn, inflammaging, and PD pathogenesis.

Keywords:
AgingInflammagingInflammationParkinson's diseaseα-synuclein

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Area of Science:

  • Neuroscience
  • Immunology
  • Gerontology

Background:

  • Alpha-synuclein (α-syn) is central to Lewy body pathology in Parkinson's disease (PD).
  • Aging is the primary risk factor for PD, and is associated with chronic inflammation ('inflammaging').
  • Emerging evidence suggests α-syn may interact with inflammasomes in aging.

Purpose of the Study:

  • To investigate the potential link between α-syn, aging, and Parkinson's disease.
  • To explore the role of α-syn in the immune system and its connection to inflammaging.
  • To understand how age-related inflammation influences PD.

Main Methods:

  • Literature review of studies on α-synuclein, aging, inflammasomes, and PD.
  • Analysis of the normal and abnormal functions of α-syn.
  • Examination of the concept of inflammaging and its relation to neurodegeneration.

Main Results:

  • α-syn has normal roles in cellular transport and immune cell maturation.
  • Mutations in α-syn cause familial PD, with symptoms often appearing later in life.
  • Oligomeric α-syn can stimulate pro-inflammatory signals, exacerbating PD and chronic inflammation.

Conclusions:

  • Age-related changes and inflammaging may contribute to PD onset and progression.
  • α-syn's interaction with inflammasomes during aging is a critical factor in PD.
  • Further research is needed to elucidate the complex interplay between α-syn, immunity, aging, and PD.