Related Experiment Video

Updated: May 29, 2025

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

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SARS-CoV-2 drug resistance and therapeutic approaches

Sania Batool1, Santosh Chokkakula1, Ju Hwan Jeong1

  • 1Department of Microbiology, Chungbuk National University, College of Medicine and Medical Research Institute, Cheongju 28644, Chungbuk, Republic of Korea.

Heliyon
|February 3, 2025
PubMed

Insights

As COVID-19 becomes endemic, drug resistance in SARS-CoV-2 remains a critical issue, especially for vulnerable groups. This review highlights the need for new therapies and continuous monitoring of viral mutations to combat resistance effectively.

Area of Science:

  • Virology
  • Infectious Diseases
  • Pharmacology

Background:

  • COVID-19 is transitioning to an endemic phase.
  • Drug resistance in SARS-CoV-2 poses significant challenges, particularly for immunocompromised and high-risk populations.
  • Ongoing research is crucial for developing effective therapeutic strategies.

Purpose of the Study:

  • To review the current state of SARS-CoV-2 drug resistance research.
  • To critically evaluate existing knowledge on resistance mechanisms and therapeutic options.
  • To identify areas for future research and consolidate information.

Main Methods:

  • Literature review of current research on SARS-CoV-2 drug resistance.
  • Critical evaluation of resistance mechanisms and antiviral therapies.
  • Analysis of viral evolution and its impact on drug efficacy.

Main Results:

  • Drug resistance in SARS-CoV-2 is an evolving challenge.
  • Existing antiviral therapies face efficacy issues due to viral mutations and emerging variants.
  • Multifaceted approaches are needed, including combination therapies and continuous surveillance.

Conclusions:

  • A comprehensive understanding of SARS-CoV-2 drug resistance is essential for effective COVID-19 management.
  • Promising strategies include drug repurposing, combination therapies, and adaptive treatment protocols.
  • Continuous surveillance of viral mutations and adaptive strategies are key to overcoming resistance.
Keywords:
Antiviral drugsDrug resistanceResistance mechanismSARS-CoV-2Therapeutic strategies

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