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Multisystem Inflammatory Syndrome in Children Versus Neonates: A Case Series
Keshav Bhattar1, Sudha S Anilkumar2, Rashma Sadasivan3
1Internal Medicine, Dr. Sampurnanand Medical College, Jodhpur, IND.
Insights
Multisystem inflammatory syndrome in children (MIS-C) and neonates (MIS-N) present similarly to Kawasaki disease. This case series details three MIS-C and three MIS-N cases to improve understanding and early diagnosis.
Area of Science:
- Pediatric Infectious Diseases
- Neonatal Immunology
- Rheumatology
Background:
- Reports of multisystem inflammatory disease in children post-SARS-CoV-2 infection led to the CDC's MIS-C case definition.
- A similar condition in neonates is termed multisystem inflammatory syndrome in neonates (MIS-N).
- Clinical overlap exists between MIS-C, MIS-N, and Kawasaki disease (KD).
Observation:
- This case series presents three cases of MIS-C and three cases of MIS-N.
- The cases highlight the clinical similarities and diagnostic challenges.
- Detailed case descriptions aim to elucidate specific presentations.
Findings:
- The series provides clinical data on MIS-C and MIS-N presentations.
- Observations contribute to understanding the spectrum of these inflammatory syndromes.
- Comparison with Kawasaki disease characteristics is explored.
Implications:
- Early diagnosis and treatment are critical to prevent severe complications.
- Enhanced understanding of MIS-C and MIS-N can guide clinical management.
- Further research is warranted to differentiate and manage these conditions effectively.
Abstract:
After several reports of a multisystem inflammatory disease in pediatric patients who had evidence of active or past infection with the novel coronavirus SARS-CoV-2, in May 2020, the Centers for Disease Control and Prevention (CDC) provided a case definition for this multisystem inflammatory syndrome in children (MIS-C). A similar presentation in neonates has been termed multisystem inflammatory syndrome in neonates (MIS-N). There is considerable overlap between clinical presentation for MIS-C and Kawasaki disease (KD) or atypical KD. Early diagnosis and treatment of these conditions are crucial to prevent serious complications. This case series describes three cases of MIS-C and MIS-N each and aims to provide evidence to advance the current understanding of these conditions.
