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Research Trends and Dynamics in Single-cell RNA Sequencing for Musculoskeletal Diseases: A Scientometric and
Siyang Cao1,2,3, Yihao Wei1,2,4,5,6, Yaohang Yue1,2,3
1National & Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, People's Republic of China.
International Journal of Medical Sciences
|February 3, 2025
Summary
This study analyzes 15 years of single-cell RNA sequencing (scRNA-seq) research in musculoskeletal (MSK) diseases. China leads publications, focusing on joint diseases and bone conditions, offering insights for researchers.
Area of Science:
- Biomedical Research
- Genomics
- Musculoskeletal Diseases
Background:
- 1.7 billion people globally suffer from musculoskeletal (MSK) diseases.
- Single-cell RNA sequencing (scRNA-seq) offers new insights into MSK disease mechanisms.
- A gap exists in comprehensive analyses of scRNA-seq research trends in MSK disorders.
Purpose of the Study:
- To provide a 15-year overview of scRNA-seq advancements in MSK disorders.
- To identify key research directions, focuses, and future perspectives.
- To map the current research landscape and publication trajectory.
Main Methods:
- Scientometric analysis of publications from Web of Science Core Collection (2009-2024).
- Application of advanced analytical and visual methodologies.
- Data compilation and trend identification.
Main Results:
- China dominates publications (63.49%), with Shanghai Jiao Tong University, Sun Yat-sen University, and Harvard Medical School as leading institutions.
- Liu Yun is the most prolific author, and *Frontiers in Immunology* published the most papers.
- Key research focuses include joint diseases, bone neoplasms, bone fractures, and intervertebral disc degeneration.
Conclusions:
- This scientometric analysis offers valuable data for researchers in the MSK and scRNA-seq fields.
- It facilitates access to critical information, promoting innovation and understanding.
- The study highlights major contributors and research themes, guiding future investigations.
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