Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

6.8K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
6.8K
Necrosis01:16

Necrosis

4.1K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.1K
Gene Families01:57

Gene Families

8.7K
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
8.7K
Protein Modifications in the RER01:26

Protein Modifications in the RER

5.0K
Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal...
5.0K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

8.2K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
8.2K
Globular and Fibrous Proteins02:21

Globular and Fibrous Proteins

43.3K
Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
43.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Life-course BMI trajectories and long-term weight gain in relation to hepatic steatosis in a rural community-based cohort in Southwest China.

Frontiers in public health·2026
Same author

Corrigendum to 'Wavelength-dependent photobiomodulation attenuates synovial inflammation in fibroblast-like synoviocytes and a collagenase-induced osteoarthritis model' [Journal of Photochemistry & Photobiology B: Biology Volume 272 (2025) 113276].

Journal of photochemistry and photobiology. B, Biology·2026
Same author

Highly diverse diazotrophs drive high N<sub>2</sub> fixation rates in a shallow submarine hydrothermal system.

Fundamental research·2026
Same author

Feasibility and Preliminary Effects of Inspiratory Muscle Training in Patients With Knee Osteoarthritis Awaiting Total Knee Arthroplasty: An 8-Week, Pilot Randomized Controlled Trial.

Archives of physical medicine and rehabilitation·2026
Same author

Dynamic homoeolog expression partitioning contributes to soil-driven adaptive plasticity in allopolyploid Leymus chinensis.

The Plant journal : for cell and molecular biology·2026
Same author

Healthcare Provision Shifts Under DIP Reform: From Conventional Medicine to Traditional Medicine.

Inquiry : a journal of medical care organization, provision and financing·2026
Same journal

The interplay between type 2 diabetes mellitus and sepsis: a scoping review.

International journal of medical sciences·2026
Same journal

Overcoming Biological Barriers: A Comprehensive Review of Advanced Melatonin Delivery Systems for Therapeutic Applications.

International journal of medical sciences·2026
Same journal

IFN-γ+ NK cells as a potential predictor of pregnancy loss in unexplained recurrent pregnancy loss.

International journal of medical sciences·2026
Same journal

Lutein Attenuates Synovial Hyperplasia, Cartilage Loss, and Bone Erosion by Suppressing Inflammatory Pathways in Rheumatoid Arthritis.

International journal of medical sciences·2026
Same journal

Dual Metabolic Inhibition by Berberine and Glutor Triggers AMPK/JNK-Dependent DNA Damage in Cancer Cells.

International journal of medical sciences·2026
Same journal

Polyinosinic:polycytidylic acid causes epithelial-mesenchymal transition via BAFF expression in Beas-2B human bronchial epithelial cells.

International journal of medical sciences·2026
See all related articles

Related Experiment Video

Updated: May 29, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

847

Deciphering Epigenetic and Post-Translational Modifications in Ferroptosis: A Scientometric and Visualization Study.

Siyang Cao1,2,3, Yihao Wei1,2,4,5, Yaohang Yue1,2,3

  • 1National & Local Joint Engineering Research Centre of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong, People's Republic of China.

International Journal of Medical Sciences
|February 3, 2025
PubMed
Summary
This summary is machine-generated.

This study maps 12 years of research on epigenetic alterations and post-translational modifications (PTMs) regulating ferroptosis. China leads global output, with key institutions and authors driving advancements in understanding ferroptosis mechanisms.

Keywords:
epigeneticsferroptosispost-translational modificationsscientometricsvisualization analysis

More Related Videos

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII
04:48

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII

Published on: May 4, 2020

8.0K
Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts
09:21

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Published on: February 23, 2024

810

Related Experiment Videos

Last Updated: May 29, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

847
Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII
04:48

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII

Published on: May 4, 2020

8.0K
Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts
09:21

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Published on: February 23, 2024

810

Area of Science:

  • Biomedical research
  • Molecular biology
  • Cellular mechanisms

Background:

  • Epigenetic alterations and post-translational modifications (PTMs) are crucial regulators of ferroptosis.
  • Existing literature lacks comprehensive analyses of research evolution, key themes, and future directions in this field.

Purpose of the Study:

  • To provide a comprehensive scientometric analysis of research on epigenetic modifications and PTMs in ferroptosis over the past 12 years.
  • To map research trends, identify central themes, and predict future directions in ferroptosis regulation.

Main Methods:

  • Utilized Web of Science data from January 1, 2012, to May 21, 2024.
  • Employed advanced analytical tools for scientometric assessment and visual data analysis.

Main Results:

  • China dominates global research output (69.59%), with Central South University, Shanghai Jiao Tong University, and Zhejiang University as leading institutions.
  • Liu Shuang and Tang Daolin are the most prolific authors; Cell Death & Disease is the leading journal.
  • Hepatocellular carcinoma, mitochondrial diseases, and iron overload are prominent research areas.

Conclusions:

  • This scientometric assessment offers valuable insights for researchers and newcomers.
  • It facilitates the identification of innovative concepts and future research avenues in ferroptosis regulation.