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Updated: May 29, 2025

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
Published on: March 15, 2024
Peripheral Nerve Stimulation and Improved Functional Outcomes in a Prosthetic User: A Case Report
Anupama Balasubramanian1, Casandra R Mysior2, Noel So3
1From the The Robert Larner MD College of Medicine, University of Vermont, Burlington, Vermont.
Abstract:
Peripheral nerve stimulation (PNS) is an emerging option for postamputation pain. However, its impact on prosthesis use and comfort remains underexplored. This case report describes a patient whose chronic postamputation pain limited mobility, function, and prosthesis use. After failing conservative therapies, successful treatment was achieved with sciatic PNS which improved pain, prosthesis comfort, and functional outcomes as measured by the Orthotic and Prosthetic Users Survey Lower Extremity Functional Status Measure and Prosthetic Limb Users Survey of Mobility. Although surgical techniques, such as targeted muscle reinnervation, also enhance prosthetic function, PNS offers unique advantages.

