Related Experiment Video

Updated: May 29, 2025

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

476

Relationship between programmed cell death and targeted therapy for thyroid cancer in patients with a poor prognosis:

Yuejia Zhao1, Simeng Zhao1, Zhe Fan2

  • 1Department of General Surgery, The Second Hospital of Dalian Medical University, Dalian, 116023, China.

Discover Oncology
|February 3, 2025
PubMed

Insights

Thyroid cancer pathogenesis involves programmed cell death (PCD) pathways. Understanding these PCD mechanisms offers new targeted therapy strategies for difficult-to-treat thyroid cancers.

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Medicine

Background:

  • Thyroid cancer incidence is rising, yet its carcinogenesis mechanisms remain incompletely understood.
  • Programmed cell death (PCD) is a crucial cellular process regulated by specific genes, vital for maintaining tissue homeostasis.
  • Emerging evidence highlights PCD's significant role in thyroid cancer development and progression.

Purpose of the Study:

  • To review the six identified forms of programmed cell death (PCD) relevant to thyroid cancer.
  • To analyze biomarkers associated with different PCD pathways in thyroid cancer.
  • To elucidate the role of PCD pathways in targeted therapies for advanced or refractory thyroid cancers.

Main Methods:

  • Systematic literature review of programmed cell death (PCD) pathways in thyroid cancer.
  • Analysis of existing data on PCD biomarkers in thyroid cancer.
  • Synthesis of information on the therapeutic implications of PCD pathways for various thyroid cancer subtypes.

Main Results:

  • Six distinct programmed cell death (PCD) pathways have been identified in the context of thyroid cancer.
  • Specific biomarkers are associated with different PCD pathways, offering potential diagnostic and prognostic value.
  • Various PCD pathways demonstrate potential as targets for novel therapeutic strategies in thyroid cancer.

Conclusions:

  • Programmed cell death (PCD) pathways are integral to thyroid cancer pathogenesis and represent promising targets for therapy.
  • Further research into PCD mechanisms and biomarkers can lead to improved treatment strategies for drug-resistant, poorly differentiated, and iodine-refractory thyroid cancers.
  • Accurate identification of PCD targets is essential for developing effective, personalized therapeutic approaches for thyroid cancer patients.
Keywords:
Programmed cell deathTargeted therapyThyroid cancer

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