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Prognostic value of FCER1G expression and M2 macrophage infiltration in esophageal squamous cell carcinoma

  • 0Department of Pathology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
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February 3, 2025

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February 3, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Fc fragment of high affinity IgE receptor I gamma chain (FCER1G) infiltration in esophageal squamous cell carcinoma (ESCC) correlates with poor prognosis. Combined detection of FCER1G and CD163 enhances predictive value for patient outcomes.

Area Of Science

  • Immunology and Cancer Research
  • Molecular Biology and Pathology

Background

  • Fc fragment of high affinity IgE receptor I gamma chain (FCER1G) is an immune-associated protein involved in antibody-mediated immune responses.
  • The precise role of FCER1G in various cancers, including esophageal squamous cell carcinoma (ESCC), remains incompletely understood.
  • Investigating FCER1G's association with tumor-infiltrating immune cells (TIICs) and its prognostic significance is crucial for understanding cancer progression.

Purpose Of The Study

  • To investigate the association between FCER1G expression and TIICs in ESCC.
  • To determine the prognostic value of FCER1G in ESCC patients.
  • To evaluate the combined prognostic significance of FCER1G and CD163 in ESCC.

Main Methods

  • Utilized The Cancer Genome Atlas and Gene Expression Omnibus databases to analyze FCER1G expression and prognostic value in ESCC.
  • Assessed the relationship between FCER1G expression and 22 types of TIICs.
  • Employed immunohistochemistry and double immunofluorescence to detect FCER1G, CD163, and their co-expression; survival analysis used Kaplan-Meier curves and Cox regression.

Main Results

  • FCER1G was found to be upregulated in ESCC, predominantly in the intra-tumor mesenchyme.
  • Higher FCER1G infiltration in the mesenchyme correlated with worse overall survival (OS) in ESCC patients.
  • FCER1G+ cell infiltration was positively associated with M2 macrophages, particularly CD163+ M2 macrophages, which also expressed FCER1G. Increased infiltration of FCER1G+ M2 macrophages predicted poorer OS.

Conclusions

  • FCER1G+ cell infiltration serves as a potential predictor for the prognosis of ESCC.
  • The combined detection of FCER1G and CD163 demonstrates a higher prognostic value for ESCC outcomes.
  • FCER1G and TNM stage are independent risk factors influencing the overall survival of ESCC patients.

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