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Updated: May 29, 2025
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Pd-Catalyzed/Ligand-Controlled Regioselective Asymmetric Hydrosulfonylation of Alkylallenes or Arylallenes
Jing Wu1, Boyi Wang1, Jinghan Zou1
1State Key Laboratory and Institute of Elemento-Organic Chemistry, National Engineering Research Center of Pesticide, Nankai University; College of Chemistry, Nankai University, Weijin Road 94#, Nankai District, Tianjin 300071, China.
Abstract:
The metal-catalyzed hydrofunctionalization reaction of allenes is an efficient approach for the construction of new allyl compounds. This work described a palladium-catalyzed/ligand-controlled asymmetric hydrosulfonylation of simple alkylallenes and arylallenes in the presence of Pd2dba3. Using a Josiphos or Segphos ligand, the alkylallenes or arylallenes could render the corresponding branched chiral allylsulfones with high yields and high enantioselectivities up to 90% and 99% ee, respectively.
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