[A study on administration of antibiotics during operation for prevention of postoperative infections]

Two antibiotics, piperacillin (PIPC) and cefoperazone (CPZ) were administered during operation and determined of efficacy for prevention of postoperative infections. Following administration of PIPC and CPZ during operation, high serum concentrations were obtained. In exudates not so high concentrations were achieved with either PIPC or CPZ. This was considered to be probably due to the period and methods of collection of specimens used in this study. Bacteriological studies of washings of wounds obtained during operation gave negative results in all cases. It was considered that administration of antibiotics during operation may suffice for prevention of postoperative infections for all cases with relatively short operation time excepting for cases operated for malignant tumors or urinary tract lithiasis.